4) Support joint health
a) Support relief from joint pain
In a placebo-controlled, double-blind clinical trial, 21 Japanese men and women (aged 45-75) who had self-reported knee joint pain were orally administered 75mg Elastin F, a combination of 75mg Elastin F and 1000mg glucosamine or placebo daily for 12 weeks. After 12 weeks, the subjects completed JKMO questionnaire to assess improvement of joint pain, with higher JKOM score indicates more pain and physical disability. Based on the results, Elastin F was found to have a therapeutic impact on knee joint pain. Furthermore, the synergistic effects of Elastin F and glucosamine reduced the knee pain to a greater extent.
Student’s t-test; #p < 0.1, *p < 0.05, **p < 0.01 vs. Placebo
Dunnett’s test; ap < 0.05, bp < 0.01 vs. 0w
b) Support ligament health
Study 1: Ligament is a connective tissue that connects bones to other bones in joints. This connective tissue contains both collagen and elastin, which allows the ligament to stretch to certain extent. Ligament damage, which often occurs from a sports injury, could severely limit proper knee movement (such as inability to turn or twist the leg).
In an in vitro study, human ligament cells were used to determine the effectiveness of Elastin F and Pro-Gly peptides on ligament. Pro-Gly is the elastin peptide present in blood plasma after oral ingestion of elastin. Based on the results, both Elastin F and absorbed peptides (Pro-Gly) promoted cell proliferation, collagen and elastin mRNA synthesis in a dose-dependent manner.
b) Repair of ligament damage
In an animal test, rabbit models of ligament damage (aged 12 weeks) were used to determine therapeutic capability of Elastin F. In this test, the rabbits were orally administered 125 mg/kg/day Elastin F or control for 6 weeks and their physical strength was assessed. From the results, Elastin F was found to help mitigate ligament damage and improve physical strength. In other words, Elastin F helps maintain healthy joint function by strengthening ligament. Besides, it also aids the full recovery of damaged ligament.