11) Improve gastrointestinal health
Gamma oryzanol has therapeutic potential for numerous gastrointestinal diseases, including gastric ulcers and colon inflammation.
Study 1: In a test, gamma oryzanol was shown to suppress histamine- and tetragastrin-stimulated gastric secretion and experimental ulcers in subjects. The suppressive effect of gamma oryzanol on gastric secretion was proposed to be mediated by the vagus nerve, which plays a role in the action of gastrin, a hormone that stimulates the secretion of gastric acid (Nihon Yakurigaku Zasshi. 74(2):285-295 (1978)).
Study 2: In another test, experimental colitis was induced in subjects by 1% DSS (dextran sulphate sodium) in drinking water for 16 days with or without 50mg/kg/day gamma oryzanol. Gamma oryzanol was found to improve DSS-induced colon inflammation. This improvement was associated with the suppression of myeloperoxidase (MPO) activity (inflammation marker), decreased production of cytokines such IL-1β, TNF-α, and IL-6, and inhibition of COX-2 and NF-κB activity in colitis tissue. In addition, in vitro assay demonstrated that gamma oryzanol has strong antioxidant effects comparable to those of α-tocopherol. These findings suggested the beneficial effects of gamma oryzanol for treatment of gastrointestinal complaints.