Rice bran, a by-product derived from processing rice, is a rich source of bioactive compounds, including gamma oryzanol.
In this animal test, the efficacy of single and chronic supplementation of fermented rice bran for metabolic syndrome in stroke-probe spontaneously hypertensive rat (SHRSP) was evaluated. Results showed that single-dose administration of fermented rice bran (2 g/kg body weight) reduce systolic blood pressure, while chronic administration with 5% fermented rice bran for 4 weeks significantly reduced both systolic and diastolic blood pressure. In addition, rice bran supplementation improved leptin impairment and increased serum adiponectin levels and angiotensin-converting enzyme inhibitory activity. Furthermore, supplementation of fermented rice bran improved glucose tolerance and insulin sensitivity, serum insulin levels, as well as lipid profiles. In brief, dietary supplementation of fermented rice bran or possibly gamma oryzanol potentially helps reduce hypertension and alleviates metabolic syndrome.