A: VesseCLEAR EX is a natural supplement formulated with pure, concentrated nattokinase NSK-SD® and Elastin F. These 2 key ingredients work synergistically to support clear, flexible & supple blood vessels, which is vital for healthy blood flow, blood pressure and cardiovascular function.


A: Nattokinase is an enzyme extracted from a popular traditional Japanese food, “natto” that dates back to more than 1000 years. Nattokinase is proven to have strong fibrinolytic activity that can help to dissolve fibrin, a web-like structure that forms the basis of blood clot. Since nattokinase is effective in breaking down blood clot (thrombus), it has been used as a natural remedy for heart and circulatory diseases. NSK-SD® (Natural Super Kinase-Sprayed Dried) is a proprietary nattokinase developed by Japan Bio Science Laboratory Co., Ltd, the world leader and pioneer in nattokinase. It is extracted from non-GMO soybeans which were fermented with Bacillus subtilis natto, via a proprietary process (Patents: JP3834048, JP3881494) to result in high purity, maximal bioavailability and stability. The safety and efficacy of NSK-SD® has been affirmed in numerous human clinical studies.

A: Elastin is a rubber-like protein that is critical to the elasticity and resilience of many tissues, including arteries, skin, cartilage, tendon and ligament. It is roughly 1000 times more flexible than collagens and is wrapped around coil-like collagen, providing high flexibility to many tissues, allowing them to resume their shape after stretching or contracting. The aorta, which is the largest artery from the heart contains a high proportion (~50%) of elastin fibres. This elasticity helps maintain a relatively constant pressure in the artery despite the pulsating nature of the blood flow from the heart. With age, the elastin degenerates and causes arteries to stiffen. This imposes more strain on the heart and could potentially increase the risk of heart failure, stroke, heart attack or sudden death. Elastin F is a premium quality, readily absorbable elastin peptide that helps replenish the elastin in the artery wall. Extracted from bonito fish via a proprietary enzymatic technology from Japan, this low-molecular-weight peptide is highly safe, readily absorbed and research proven to support elastic and flexible blood vessels.

A: No, it does not contain vitamin K2. When looking for a quality nattokinase, always look for the one with the vitamin K2 removed. Natto is one of the richest sources of vitamin K2 that may increase blood clotting. Vitamin K2 is also known to reduce the effectiveness of Warfarin (anticoagulant) and thus, avoided by Warfarin users. By removing vitamin K2 during the production of NSK-SD®, any potential adverse drug interactions with Warfarin may be eliminated. However, it is advisable to consult physician before taking VesseCLEAR EX with medications.


A: Although the production of nattokinase involves the use of soy medium, the remaining soy left after nattokinase extraction and purification is very minimal. However, we do advise you to consult your physician if you have an allergy to soy.

A: No, it would not. Eating natto food which is high in purine may increase blood uric acid levels, and in turn, exacerbate gout. Nonetheless, Nattokinase NSK-SD®, which was extracted via a patented process, is free of purine and safe for those with high uric acid or gout problems.

A: The safety of VesseCLEAR EX Nattokinase NSK-SD® has been tested in various human clinical studies. Besides, the raw materials used in the making of nattokinase NSK-SD® have been certified non-GMO, meaning no genetically modified organisms were used in the manufacturing process. Elastin derived from bovine ligaments has long been used for nutraceuticals and cosmetics. However, the increased concern for mad cow disease has urged researchers to look for a safe, alternate source of elastin. Thus, the Elastin F in VesseCLEAR EX is extracted from bonito fish and not from bovine. The safety of this elastin has been supported by extensive studies.

A: As VesseCLEAR EX is a natural supplement and not a medicine, its effects may vary from person to person. However, most users would be able to see an improvement in blood circulation in days, which includes relief of cold or numb fingers. For supporting healthy blood pressure, it may take weeks to observe the difference.

A: Yes, VesseCLEAR EX helps support healthy blood circulation and allows blood to flows smoothly throughout the body. Increasing age is associated with decreased fibrinolytic activity and increased platelet aggregability. Thus, our blood become thicker as we get older. Nattokinase NSK-SD® helps dissolve fibrin (a main component of blood clot) and suppress platelet aggregation, hence supporting healthy blood flow and circulation.

A: Yes. VesseCLEAR EX Nattokinase NSK-SD® was research proven to reduce elevated pressure in hypertensive subjects. NSK-SD® is a powerful enzyme that breaks up fibrin clotting agents naturally. This action could help improve blood flow and thus, support healthy blood pressure. Besides, Elastin F in VesseCLEAR EX which helps support elastic and flexible arteries also plays a role in maintaining a relatively constant pressure. However, those taking prescription blood thinner are advised to consult physician before taking VesseCLEAR EX.

A: No, it will not. VesseCLEAR EX Nattokinase NSK-SD® dissolves fibrin in the clot, which is then excreted by the kidneys. Thus, it will not spread to other parts of the body and create a stroke or any health problems.

A: VesseCLEAR EX is intended for adult use on a regular basis, especially those who are over 40 years old, highly stressed, have relatively high blood pressure or high blood viscosity. It is also suitable for those who have higher risk or compromised cardiovascular health such as irregular heartbeat, chest pain, stroke etc. People with poor blood circulation such as cold or numb hands and feet, varicose vein as well as deep vein thrombosis are also encouraged to take VesseCLEAR EX. Please consult your physician before taking any dietary supplements if you have or have had any health condition.

A: The recommended daily dosage is 1 capsule, which contains 100mg of nattokinase NSK-SD® providing 2,000 FU of activity and 75mg of Elastin F. These active ingredients are in functional dosage to support clear, unclogged and flexible blood vessels.

A: FU stands for fibrin units, which is an activity unit that quantifies an enzyme’s ability to lyse fibrin found in blood clots. Nattokinase is measured in FU as opposed to milligrams or international units. This is officially adopted by the Japan NattoKinase Association (JNKA) and the Japan Health and Nutrition Food Association (JHFA) as the standard measurement of nattokinase activity.

A: No, VesseCLEAR EX is a natural supplement. It is not a medicine and hence, no prescription is required.

A: VesseCLEAR EX can be taken anytime, as long as 2 hours from any medications or 12 hours from blood thinners (if you are allowed to do so after consulting a physician). Nonetheless, if you are not on medication, it is preferably taken after dinner or before bedtime. Since thrombosis (formation of blood clot in blood vessel) is more likely to happen at dawn and most heart attacks and strokes happen in the early morning, this should grant a greater degree of protection.

A: No, it is not. Though Nattokinase NSK-SD® is made with vegan ingredients, VesseCLEAR EX also contains Elastin F which is extracted from bonito fish.

A: Yes, you can. However, do keep a 2-hour gap between VesseCLEAR EX and medicine to ensure that the efficacy of VesseCLEAR EX is not compromised. Individuals on blood thinning therapy should seek medical advice before taking.


A: According to clinical studies, VesseCLEAR EX Nattokinase NSK-SD® (3 doses of 2,000 FU a day) was safely administered along with heparin (3,800 IU twice a day by hypodermic injection) and antiplatelet drug (150 – 325 mg aspirin or clopidogrel). Besides, nattokinase NSK-SD® was also safely administred as a complement to warfarin at a dosage up to 3,400 FU (2 doses of 1,700 FU) per day. However, the use of VesseCLEAR EX along with medications should be done under the close supervision of a physician and regular blood monitoring is important. It is possible that taking nattokinase while you are taking blood thinner may reduce the required dosage for the medication. Please consult your physician for guidance on this.

A: Nattokinase NSK-SD® and Elastin F in VesseCLEAR EX have not been studied for use during pregnancy and nursing. If you are pregnant or nursing, we strongly encourage you to consult your physician before taking any supplements.

A: The major difference between lumbrokinase and nattokinase is their source. Nattokinase originates from natto (soybeans) whereas lumbrokinase comes from cells of intestinal tissue and fluid of earthworm. However, lumbrokinase acts similarly to nattokinase, that is to prevent and dissolve blood clots. Since they have similar actions, usually one or the other is used. Besides, any contraindications to using both of them concurrently are still unknown and thus, you are not advisable to use them at the same time.

A: Although both ginkgo and VesseCLEAR EX help improve blood flow, both of them work through different pathways. Ginkgo appears to dilate small blood vessels and make blood less sticky, thereby increasing blood flow to legs, ears, eyes and brain. On the other hand, VesseCLEAR increases blood flow by dissolving blood clot in blood vessels, inhibiting platelet aggregation, suppressing harmful blood clot formation and supporting elastic blood vessels. Besides, research found that ginkgo does not prevent heart attack, stroke or death, whereas nattokinase is suggested by research as a powerful prophylactic approach for heart attack and stroke.